Dual contrast CMR for evaluation of telmisartan and amlodipine combination therapy in the diabetic murine myocardial injury model
نویسندگان
چکیده
Background Combination therapy has been shown to improve cardiovascular outcomes in hypertensive, diabetic patients. Amlodipine demonstrates beneficial pleiotropic effects including improved endothelial function, enhanced angiogenesis, and reduced cardiovascular risk. Telmisartan exhibits similar beneficial cardiovascular effects in diabetic patients. Amlodipine in combination with telmisartan may provide a synergistic benefit. In this study, dual contrast CMR, using manganese (manganese-enhanced MRI; MEMRI) and gadolinium (delayed-enhanced MRI; DEMRI), will evaluate the viable myocardium and myocardial scar, respectively, to investigate the underlying mechanism of combined telmisartan and amlodipine therapy.
منابع مشابه
Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region
BACKGROUND A novel MRI technique, employing dual contrast manganese-enhanced MRI (MEMRI) and delayed enhancement MRI (DEMRI), can evaluate the physiologically unstable peri-infarct region. Dual contrast MEMRI-DEMRI enables comprehensive evaluation of telmisartan to salvage the peri-infarct injury to elucidate the underlying mechanism of restoring the ischemic cardiomyopathy in the diabetic mous...
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عنوان ژورنال:
دوره 15 شماره
صفحات -
تاریخ انتشار 2013